This study describes first evidence of a potential non-inferior treatment to the gold standard treatment for UC.34, A plant mixture extract containing myrrh has been shown to reduce the rate of gluconeogenesis in hepatocytes of rats. The authors of this study suggest that Mirazid is safe and effective for the treatment of S. haematobium and S. mansoni infections.18, In another study, 21 children with fascioliasis (mean age, 10 years) and 8 children with S. mansoni (mean age, 11 years) received 10 mg/kg/day of myrrh (Mirazid) 1 hour before breakfast for 6 consecutive days (fascioliasis) or 3 consecutive days (schistosomiasis). It has also been used as an astringent, as an antiseptic to be applied to inflamed lesions of the throat and mouth, and as an emmenagogue and an antispasmodic, and for the treatment of cancer and infectious diseases. Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs). It was commonly included in mixtures used to treat worms, wounds, and sepsis during the 4th century BC.4 Myrrh has also been reported to treat gout, headache, jaundice, throat ailments, indigestion, fatigue, and paralysis.5 Myrrh has been used in a variety of infectious diseases, including leprosy and syphilis, and to treat cancers.2 The Chinese have used myrrh in the management of a variety of skin and mouth infections.4 During the 10th century, myrrh was recommended to protect against plagues when travelling in endemic areas.4 It was also believed by the Greeks and Romans to be effective in the treatment of snake bites and is still used in parts of East Africa today for this indication.4 Myrrh was one of the first treatments of cough in children.4 Additionally, myrrh was incorporated as part of the mummification and cremation processes.4 Lotions containing myrrh have been made for use as cleansing agents, moisturizers, skin lesion treatments, and fragrances.5 Myrrh played a key role in the religious ceremonies of the ancient Egyptians.6 In the Bible, myrrh is cited as one of the 3 gifts (in addition to gold and frankincense) presented to Jesus by the Magi following his birth (Matthew 2:11) and was offered in a mixture of wine to Jesus during his crucifixion as an anesthetic (Mark 15:23).4 These gifts were a sign of wealth because they were rare and expensive.5 Myrrh is also a part of African, Middle Eastern, and Chinese traditional medicine. Additionally, a paste containing 800 mg of bee propolis and 50 g of myrrh mixed in honey was applied topically to the wound. Available for Android and iOS devices. It is also used as a stimulant and to increase menstrual flow. El-Sherbiny GM, El Sherbiny ET. Chen Y, Zhou C, Ge Z, et al. The most common adverse reactions were giddiness, somnolence, mild fatigue, and abdominal pain.20, A study was conducted to assess the efficacy of Mirazid compared with praziquantel in 459 children between 12 and 18 years of age and 672 household contacts. This study concluded that myrrh may have a potential role as a chemoprophylactic agent for the prevention of schistosomiasis. J Egypt Soc Parasitol 2008 Aug; 38(2):399-418. Those with S. mansoni had a 91% cure rate. Four weeks following treatment, 91% of patients with fascioliasis and 100% of patients with schistosomiasis who received Mirazid experienced a parasitologic cure. Baral S, Cho DH, Pariyar R, et al. Al-Jaroudi D, Kaddour O, Al-Amin N. Risks of myrrh use in pregnancy. Abyssinian Myrrh, African Myrrh, Amyris kataf, Arabian Myrrh, Bal, Balsamodendron Myrrha, Balsamodendrum habessinicum, Balsamodendrum myrrha, Bdellium, Bol, Bola, Commiphora, Commiphora abyssinica, Commiphora erythraea, Commiphora habessinica, Commiphora kataf, Commiphora madagascariensis, Commiphora molmol, Commiphora myrrha, Common Myrrh, Didin, Didthin, Gomme de Myrrhe, Gum Myrrh, Heerabol, Hemprichia erythraea, Mirra, Mirrh, Mo Yao, Murrah, Myrrh Gum, Myrrha, Myrrhe, Myrrhe Africaine, Myrrhe Amère, Myrrhe d’Arabie, Myrrhe Bisabol, Myrrhe Douce, Myrrhe de Somalie, Myrrhe du Yémen, Opopanax, Resina Commiphorae, Somalien Myrrh, Yemen Myrrh. Eggs had completely disappeared within 3 weeks following treatment and remained eradicated up to the 3-month follow-up. The effect of Commiphora molmol (Myrrh) in treatment of trichomoniasis vaginalis infection. These tears are approximately the size of a walnut and form the basis of myrrh resin. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. J Ethnopharmacol 1997;55:141-50. (This myrrh is in small yellowish or white globules or tears. Cochrane Database Syst Rev 2013 Feb 28; (2). Local anesthetic activity was also noted in mammalian nerve cells.11, In a case report, a 65-year-old man with diabetes had a wound on his right foot with tissue loss. Chemotherapy 1994:40:337-47. (check all that apply). The subjects were given myrrh or Mirazid in doses ranging from 180 mg/kg to 10,000 mg/kg for 6 to 8 weeks following infection. View abstract. Thought to be effective for pain relief, including menstrual pain resulting from blood stagnation. Iran Red Crescent Med J 2011;13(7):480-6. Asian Pac J Trop Biomed 2013;3(6):501-4. Early research shows that taking a product containing myrrh and other ingredients might prevent symptoms returning in people with ulcerative colitis. Due to its antimicrobial properties, myrrh has traditionally been used to treat oral infections and inflammation . Myrrh was found to enhance their white blood cell counts, which “have been used as an indicator by clinicians to monitor progress of healing in patients” . This is only a brief summary of general information about this product. It was also suggested that cytokine levels may be evaluated to assess cure.19, Another study in Egypt involved 204 patients ranging from 12 to 68 years of age with schiostomiasis. The Commiphora species that serve as sources of myrrh are thorny shrubs or small trees that grow to up to 3 meters high. No adverse reactions were reported.14, An in vitro study of 2 sesquiterpenes derived from myrrh (furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one) discovered antibacterial activity against Pseudomonas aeruginosa (minimum inhibitory concentration [MIC] 1.4 mcg/mL), Staphylococcus aureus (MIC 0.18 mcg/mL), and Escherichia coli (MIC 2.8 mcg/mL). Trichomoniasis is a sexually transmitted disease caused by a parasite. This makes it a great aid in mouth ulcers, tooth problems, and other oral issues. IL-4 levels were not significantly different prior to treatment with myrrh (P = 0.58; 0.72, respectively) but increased significantly following treatment for patients with fascioliasis and schistosomiasis (P = 0.04; 0.02, respectively). View abstract. Myrrh may be administered as a tincture or in dental powders, tea, rinses, and gargles. Therefore, products containing myrrh may interact with warfarin and other coumarin derivatives.31, Myrrh has demonstrated the ability to lower blood sugar levels. Myrrh has long been used in parts of Asia as a traditional medicine for inflammatory diseases. Commiphora mukul, a related species, is not a source of myrrh. After the second treatment, the cure rate for patients treated with myrrh was 9%, compared with 76% of patients receiving praziquantel (P < 0.05). Myrrh has long been used for oral treatments. 2010 Sept; 16(9):932-6. This study suggests that the value of myrrh in the treatment of schistosomiasis is questionable.21, In one Egyptian village, patients were screened for the presence of S. mansoni; prevalence was determined to be 15%. They are native to Africa, eastern Mediterranean countries, and South Arabia. This study suggested that myrrh extract may have a role as an antischistosomal agent.15, In a multicenter investigation, mice and hamsters were infected with various strains of S. mansoni. The appropriate dose of myrrh depends on several factors such as the user's age, health, and several other conditions. A cure rate of 27% was reported for a control group, which was randomized but consisted of household contacts who didn't receive therapy. View abstract. It is myrrh essential oil, diluted in or blended with a carrier oil. Anticarcinogenic effect of Commiphora molmol on solid tumors induced by Ehrlich carcinoma cells in mice. In group 3, the mice had marked reductions in granulomas and fibrosis. Warfarin (Coumadin) is used to slow blood clotting. Did you or will you purchase this product in-store or online? A pale yellow-white viscous liquid exudes from natural cracks or fissures in the bark or from fissures cut intentionally to harvest the material.3 When air-dried, this exudate hardens into a reddish-brown mass that often contains white patches. Careful monitoring of blood glucose is warranted.9, 25, Although myrrh is generally considered to be nonirritating, nonsensitizing, and nonphototoxic to human and animal skin2 several cases of dermatitis caused by myrrh have been reported.32 In case reports of 2 patients using transdermal myrrh formulations for tendonitis, both developed contact dermatitis at the application sites within a few weeks of administration. Myrrh oil can also be made at home with myrrh … The scent of myrrh on its own is strong, sweet, and somewhat bitter and earthy. This survey is being conducted by the WebMD marketing sciences department. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. View abstract. For instance, both are commonly used in traditional Chinese medicine, Ayurveda and aromatherapy. Myrrh may interact with warfarin and other coumarin derivatives, resulting in a reduction in the international normalized ratio (INR). By the completion of therapy (6 days), the average egg count was 6 ± 2 eggs per g of stool. Additionally, these sesquiterpenes demonstrated antifungal activity against Candida albicans (MIC 1.4 mcg/mL). Shalaby MA, Hammouda AA. This is the ready-to-use version since myrrh essential oil is too strong to be applied directly on the skin or to be used for any other purpose. For 12 patients who had never received treatment with praziquantel, the cure rate associated with myrrh was 100%. Avoid use in pregnancy and lactation.8, 9, 30 Myrrh is considered to be an emmenagogue and an abortifacient. turmeric, saw palmetto, Ginkgo Biloba, garlic, echinacea. Myrrh is traditionally used as burned incense which repels fleas and mosquitoes. View abstract. According to this Bible Study Tools article, myrrh dates back to Exodus when the Israelites would use myrrh as a main ingredient in holy anointing oil (Exodus 30:23). Myrrh might decrease blood sugar. Although myrrh's exact role in wound healing is difficult to determine because of many confounding factors in this case report, data suggest there may be a potential role for topically applied products containing myrrh.6, Myrrh has a locally stimulating action on smooth muscle tissue and may stimulate peristalsis.22, 23 By contrast, T-cadinol has a concentration-dependent smooth muscle relaxing effect on the isolated guinea pig ileum and a dose-dependent inhibitory effect on cholera toxin-induced intestinal hypersecretion in mice.12, Pretreatment with an aqueous solution of C. molmol provided dose-dependent protection against the development of GI ulcers in rats that received ethanol, 25% NaCl, 0.2 M NaOH, indomethacin, and combination ethanol and indomethacin. Avoid use. The overall cure rate was 91% for all infected patients. Myrrh is approved by the FDA for food use and was "given generally recognized as safe" status as a flavoring agent.14. The livers of the mice in group 1 had a normal ultrastructural profile. The cure rates for patients in the moderate- and heavy-infection groups were 0%. Myrrh is usually collected in the summer months.2, 3, 4 Though related, Commiphora mukul or "false" myrrh does not provide a source of myrrh, but rather guggulu resin, which is believed to lower cholesterol levels.4, Myrrh has been used for centuries3 as incense and for medicinal purposes.4 Medicinally, it has been used as an astringent, antiseptic, antiparasitic, antitussive, emmenagogue, and antispasmodic agent. Group who did not respond to the wound was cleaned daily followed by application of the paste may fit... Loss of the kidney, bladder, or approved for treating any patient or health condition sugar levels news new... Abyssinica ( Bevg. treatment and remained eradicated up to 3 meters high effect Commiphora! ; ( 2 ) myrrh for 6 to 8 weeks following treatment and... 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